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Semin Neonatol. 2000 Feb;5(1):3-16.

Mechanisms of perinatal brain injury.

Author information

1
Department of Paediatrics, Christchurch School of Medicine and Hospital, University of Otago, Christchurch, New Zealand.

Abstract

This article is focused on the mechanisms underlying primarily ischaemic/reperfusion brain injury in both the term and premature infant. Although the mechanisms involved include similar initiating events, principally ischaemia-reperfusion, and similar final common pathways to cell death, particularly free radical-mediated events, there are certain unique maturational factors influencing the type and pattern of cellular injury. We will therefore initially describe the physiological and cellular/molecular mechanisms of brain injury in the term infant, followed by the mechanisms in the premature infant.

PMID:
10802746
DOI:
10.1053/siny.1999.0112
[Indexed for MEDLINE]

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