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Structure. 2000 Apr 15;8(4):R77-81.

So do we understand how enzymes work?

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Blackett Laboratory, Imperial College, London, SW7 2BZ, UK.


Between 1930 and 1975 biochemical and structural analysis of enzymes led to a clear set of ideas that might form a basis for detailed understanding of enzyme action. Further development required energetic and thermodynamic analysis of enzymes in an aqueous medium, beyond the computational power then available. Structural enzymology advanced in other directions, but the fundamental questions of enzyme action must soon be re-opened.

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