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Curr Opin Cell Biol. 2000 Jun;12(3):308-19.

Centromeres: getting a grip of chromosomes.

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Human Genetics Unit, Medical Research Council, Western General Hospital, Edinburgh, EH4 2XU, UK.


On monocentric chromosomes the centromere is the chromosomal site at which the kinetochore complex is assembled. This complex mediates the attachment and movement of chromosomes along spindle microtubules. The centromere is usually the last site to retain cohesion between sister centromeres. The location of the main sensor for defective spindle assembly at the kinetochore allows the release of this cohesion, and thus progression through mitosis, to be held in check until key events have been completed. The intricate nature of the centromere-kinetochore complexes and the events they co-ordinate and react to is presently being dissected by studies in several organisms. In particular, several new kinetochore proteins have been identified in many organisms over the last year.

[Indexed for MEDLINE]

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