Format

Send to

Choose Destination
See comment in PubMed Commons below
Curr Opin Cell Biol. 2000 Jun;12(3):326-33.

Acetylation and chromosomal functions.

Author information

  • 1Department of Microbiology, Box 800733, University of Virginia, Health Science Center, Charlottesville, VA 22908-0733, USA.

Abstract

Since the initial discovery of histone acetyltransferases, numerous reports have established that histone acetyltransferases and histone deacetylases regulate transcription by acetylating and deacetylating histones, respectively. Recent studies have focused on the effects of histone acetylation on gene expression regulation during development and the roles of histone hypoacetylation in the maintenance of centromeric structure, X-inactivation and genomic imprinting. Recent findings have also shown that the functions of non-histone proteins can also be regulated by acetylation. Together, these data highlight the importance of acetylation of histones and non-histone proteins in a variety of chromosomal functions.

PMID:
10801466
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk