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Curr Opin Cell Biol. 2000 Jun;12(3):346-50.

Functions of Lsm proteins in mRNA degradation and splicing.

Author information

1
Department of Molecular and Cellular Biology, Howard Hughes Medical Institute, University of Arizona, Tucson 85721, USA.

Abstract

Recent results have identified a family of Lsm (Like Sm) proteins that are related to the Sm protein family. Seven Lsm proteins form a complex, which interacts with the U6 snRNA and functions in splicing. In addition, a different complex of Lsm proteins interacts with cytoplasmic mRNA and promotes its turnover. These diverse functions of Lsm proteins suggest that they are important modulators of RNA biogenesis and function.

PMID:
10801455
DOI:
10.1016/s0955-0674(00)00098-3
[Indexed for MEDLINE]

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