Prions: Portable prion domains

R B Wickner; K L Taylor; H K Edskes; M L Maddelein

doi:10.1016/s0960-9822(00)00460-7

Prions: Portable prion domains

Curr Biol. 2000 May 4;10(9):R335-7. doi: 10.1016/s0960-9822(00)00460-7.

Authors

R B Wickner¹, K L Taylor, H K Edskes, M L Maddelein

Affiliation

¹ Laboratory of Biochemistry and Genetics, NIDDK, NIH, Bethesda, 20892-0830, USA. wickner@helix.nih.gov

PMID: 10801430
DOI: 10.1016/s0960-9822(00)00460-7

Abstract

Self-propagating abnormal proteins, prions, have been identified in yeast; asparagine/glutamine-rich 'prion domains' within these proteins can inactivate the linked functional domains; new prion domains and reporters have been used to make 'synthetic prions', leading to discoveries of new natural prions.

Publication types

Review

MeSH terms

Animals
Binding Sites
Fungal Proteins / metabolism*
Glutathione Peroxidase
Peptide Termination Factors
Prions / metabolism*
Saccharomyces cerevisiae / metabolism
Saccharomyces cerevisiae Proteins*

Substances

Fungal Proteins
Peptide Termination Factors
Prions
SUP35 protein, S cerevisiae
Saccharomyces cerevisiae Proteins
Glutathione Peroxidase
URE2 protein, S cerevisiae