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Curr Biol. 2000 Apr 20;10(8):R302-4.

To differentiate or not to differentiate?

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Department of Biology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill 27599, USA.


Developmental regulation of the cell cycle is an important determinant of tissue size and shape. Equally important is regulated withdrawal from the cell cycle to allow cells to differentiate. Recent evidence supports a direct link between transcriptional regulation of the cell cycle machinery and cell differentiation.

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