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Curr Biol. 2000 Apr 20;10(8):R315-7.

How to activate p53.

Author information

1
MRC Cell Mutation Unit, University of Sussex, Brighton, BN1 9RR, UK. T.Caspari@sussex.ac.uk

Abstract

The tumour suppressor protein p53 is stabilised and activated in response to ionising radiation. This is known to depend on the kinase ATM; recent results suggest ATM acts via the downstream kinase Chk2/hCds1, which stabilises p53 at least in part by direct phosphorylation of residue serine 20.

PMID:
10801407
[Indexed for MEDLINE]
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