Format

Send to

Choose Destination
See comment in PubMed Commons below
Bone Marrow Transplant. 2000 May;25(9):981-5.

Encouraging results in the treatment of haemorrhagic cystitis with estrogen - report of 10 cases and review of the literature.

Author information

1
Department of Medicine I, Technical University of Dresden, University Hospital 'Carl Gustav Carus', Dresden, Germany.

Abstract

Haemorrhagic cystitis (HC) after allogeneic haematopoietic stem cell transplantation (HSCT) or high-dose cyclophosphamide (CP) chemotherapy is a severe side-effect and can cause significant morbidity and mortality. In this report, we describe the clinical courses of 10 patients with HC and review the literature. The patients were treated with oral conjugated estrogen in an attempt to improve severe haemorrhagic cystitis. In seven patients positive effects were seen, haematuria resolved in all, but residual symptoms of dysuria remained for longer periods. In one patient application of estrogen was interrupted because of hepatotoxicity. Two patients failed all treatment modalities including oral estrogen because of terminal illness. We conclude that in the management of HC the administration of oral conjugated estrogen should be considered.

PMID:
10800067
DOI:
10.1038/sj.bmt.1702380
[Indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group
    Loading ...
    Support Center