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Biochem Pharmacol. 1999 May 1;57(9):975-9.

Receptors mediating adenovirus attachment and internalization.

Author information

1
Division of Immunologic and Infectious Diseases, Children's Hospital of Philadelphia, PA 19104, USA. bergelson@email.chop.edu

Abstract

Adenovirus infection requires that the virus attach to cells and be internalized. Interaction between the viral fiber protein and specific cell surface receptors, such as the 46-kDa coxsackievirus and adenovirus receptor (CAR), is responsible for attachment; a second interaction between the viral penton base and cell surface integrins facilitates virus internalization. Expression of receptors may determine whether tissues are susceptible to adenovirus infection and adenovirus-mediated gene delivery.

PMID:
10796067
DOI:
10.1016/s0006-2952(98)00332-3
[Indexed for MEDLINE]

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