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Clin Exp Allergy. 2000 May;30(5):651-6.

Association between HLA genes and susceptibility to toluene diisocyanate-induced asthma.

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1
Institute of Occupational Medicine, University of Padova, Italy.

Abstract

BACKGROUND:

Only a small proportion of subjects exposed to isocyanates develop occupational asthma, suggesting individual predisposition. The human leucocyte antigen (HLA) class II molecules may play a crucial role in the development of the immune response to isocyanates.

OBJECTIVES:

To investigate the role of HLA class II molecules in the development of toluene diisocyanate (TDI)-induced asthma.

SUBJECTS:

Sixty-seven asthmatic subjects and 27 asymptomatic exposed subjects (controls) were typed at the HLA class II DQA1, DQB1 and DRB1 loci by polymerase chain reaction (PCR)-based techniques.

RESULTS:

The frequencies of DQA1*0104 and DQB1*0503 were significantly increased in asthmatics compared with asymptomatic exposed subjects, while DQA1*0101 and DQB1*0501 were significantly increased in asymptomatic exposed subjects. No significant difference was found in the distribution of DRB1 alleles between asthmatics and controls.

CONCLUSIONS:

The results of this study indicate that HLA-regulated immune mechanisms are involved in TDI-induced asthma and that, in exposed subjects, specific factors may increase or decrease the risk of developing disease.

[Indexed for MEDLINE]

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