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Lancet. 2000 Apr 1;355(9210):1176-8.

The taxanes: an update.

Author information

1
St Vincent's University Hospital, Dublin, Ireland. John.Crown@ICORG.IE

Abstract

The taxanes are anticancer cytotoxics that stabilise cellular microtubules. Two members, paclitaxel and docetaxel have substantial activity. One or both agents are widely accepted as evidence-based components of therapy for advanced breast, lung, and ovarian carcinomas. Paclitaxel has recently been approved in the USA for the adjuvant treatment of early stage node-positive breast carcinoma.

PMID:
10791395
DOI:
10.1016/S0140-6736(00)02074-2
[Indexed for MEDLINE]

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