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Electrophoresis. 2000 Apr;21(6):1164-77.

Recent advancements in surface-enhanced laser desorption/ionization-time of flight-mass spectrometry.

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Ciphergen Biosystems, Inc., Palo Alto, CA 94306, USA.


The overall history and recent advances in surface enhanced laser desorption/ionization-time of flight-mass spectrometry (SELDI-TOF-MS) technology is reviewed herein. Fundamentals of SELDI-TOF analysis are presented while drawing comparisons with other laser-based mass spectrometry techniques. The application of SELDI-TOF-MS to functional genomics and biomarker discovery is discussed and exemplified by elucidating a biomarker candidate for prostatic carcinoma. Finally, a short discussion regarding future SELDI requirements and developments is supplied.

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