Measurement of thrombopoietic levels: clinical and biological relationships

Curr Opin Hematol. 2000 May;7(3):143-9. doi: 10.1097/00062752-200005000-00003.

Abstract

Platelet production is primarily regulated by the thrombopoietic cytokine thrombopoietin (TPO). In most cases thrombopoietin serum levels are determined by the rate of c-mpl receptor-mediated degradation after TPO uptake into platelets and megakaryocytes. The contribution of increased TPO protein synthesis by a translational mechanism was recently appreciated as the cause for hereditary thrombocythemia and will have to be elucidated in other conditions of thrombocytosis in association with increased TPO levels.

Publication types

  • Review

MeSH terms

  • Acquired Immunodeficiency Syndrome / blood
  • Adult
  • Animals
  • Antineoplastic Agents / adverse effects
  • Child, Preschool
  • Cytokines / blood
  • Cytokines / pharmacology
  • HIV Infections / blood
  • Hematologic Diseases / blood
  • Hematologic Diseases / chemically induced
  • Hematologic Diseases / genetics
  • Humans
  • Infant
  • Infant, Newborn
  • Neoplasm Proteins*
  • Proto-Oncogene Proteins / metabolism
  • Receptors, Cytokine / metabolism
  • Receptors, Thrombopoietin
  • Thrombocytopenia / blood
  • Thrombocytosis / etiology
  • Thrombocytosis / metabolism
  • Thrombocytosis / virology
  • Thrombopoietin / blood*
  • Thrombopoietin / drug effects

Substances

  • Antineoplastic Agents
  • Cytokines
  • Neoplasm Proteins
  • Proto-Oncogene Proteins
  • Receptors, Cytokine
  • Receptors, Thrombopoietin
  • MPL protein, human
  • Thrombopoietin