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Biochim Biophys Acta. 2000 Jan 31;1490(1-2):170-4.

A new human member of the MYST family of histone acetyl transferases with high sequence similarity to Drosophila MOF.

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Department of Biology, Emory University, Atlanta, GA 30322, USA.


We have identified a novel human gene product, hMOF, which exhibits significant similarity to the Drosophila dosage compensation regulator, MOF. A recombinant C-terminal portion of hMOF has histone acetyltransferase activity directed toward histones H3, H2A and H4, a specificity characteristic of other MYST family histone acetyltransferases. Based on hMOF's chromodomain, we discuss possible interactions with other proteins.

[Indexed for MEDLINE]

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