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Trends Pharmacol Sci. 2000 May;21(5):170-2.

Inflammation-coagulation network: are serine protease receptors the knot?

Author information

1
Dipartimento di Farmacologia Sperimentale, Federico II University of Naples, Via Domenico Montesano 49, 80131 Napoli, Italy. cirino@unina.it

Abstract

Following an injury, the body recruits a mechanism to delimit and repair tissue damage; this phenomenon is known as inflammation. Among the several different pathways that are activated during this process, which is necessary for survival, activation of the coagulation pathway is a key feature. In fact, clinical changes in blood fluidity have been closely related to ongoing inflammation. Recent evidence suggests that serine protease receptors might play a major role in the host defence mechanism at the interface between coagulation and inflammation.

PMID:
10785649
DOI:
10.1016/s0165-6147(00)01469-3
[Indexed for MEDLINE]

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