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Trends Microbiol. 2000 May;8(5):214-20.

Type III machines of Gram-negative bacteria: delivering the goods.

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Dept of Microbiology and Immunology, UCLA School of Medicine, Los Angeles, CA 90095, USA.


Many Gram-negative pathogens use a type III secretion machine to translocate protein toxins across the bacterial cell envelope. Pathogenic Yersinia spp. export at least 14 Yop proteins via a type III machine, which recognizes secretion substrates by signals encoded in yop mRNA or chaperones bound to unfolded Yop proteins. During infection, substrate recognition appears to be regulated in a manner that allows the Yersinia type III pathway to direct Yops to the bacterial envelope, the extracellular medium or into the cytosol of host cells.

[Indexed for MEDLINE]

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