Send to

Choose Destination
Science. 2000 Apr 28;288(5466):672-5.

Localization of a short-term memory in Drosophila.

Author information

Theodor Boveri Institut für Biowissenschaften, Lehrstuhl für Genetik, (Biozentrum) Am Hubland, D97074, Würzburg, Germany.


Memories are thought to be due to lasting synaptic modifications in the brain. The search for memory traces has relied predominantly on determining regions that are necessary for the process. However, a more informative approach is to define the smallest sufficient set of brain structures. The rutabaga adenylyl cyclase, an enzyme that is ubiquitously expressed in the Drosophila brain and that mediates synaptic plasticity, is needed exclusively in the Kenyon cells of the mushroom bodies for a component of olfactory short-term memory. This demonstrates that synaptic plasticity in a small brain region can be sufficient for memory formation.

[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for HighWire
Loading ...
Support Center