Format

Send to

Choose Destination
Nat Cell Biol. 2000 Apr;2(4):E65-7.

Rb function in cell-cycle regulation and apoptosis.

Author information

1
Department of Ophthalmology and Visual Sciences,Washington University, St Louis, Missouri 63110, USA.

Abstract

Loss of cell-cycle control is a hallmark of neoplastic cells. One regulator of the critical G1 to S-phase transition in the cell cycle is the retinoblastoma tumour suppressor protein Rb, which interacts with the E2F family of cell-cycle transcription factors to repress gene transcription required for this transition. Through its interaction with E2F, Rb also regulates genes that control apoptosis. Here we review the roles of Rb in regulating the cell cycle and apoptosis and discuss recent results linking these Rb functions to chromatin-remodelling enzymes.

PMID:
10783254
DOI:
10.1038/35008695
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center