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J Rheumatol. 2000 Apr;27(4):1028-31.

Bone mineral density in women with ankylosing spondylitis.

Author information

1
Rheumatology Service, Ciutat Sanitària i Universitària de Bellvitge, Hospital Princeps d'Espanya, L'Hospitalet de Llobregat, Barcelona, Spain. x.juanola@csub.scs.es

Abstract

OBJECTIVE:

To determine bone mineral density (BMD) in premenopausal women with early ankylosing spondylitis (AS).

METHODS:

Eighteen premenopausal women with AS without syndesmophytes, interapophysiary arthritis, and/or coxofemoral joint destruction were studied. BMD was analyzed at lumbar spine and femoral neck by dual energy x-ray absorptiometry (Hologic QDR 1000). Z scores and T scores related to the general Spanish population were recorded. Comparisons were performed using the Student t test. Pearson's correlation coefficients were used to study the correlation between BMD and the variables. Following the WHO classification, osteopenia was diagnosed in patients with T score between -1 and -2.5 and osteoporosis in those with T score < -2.5 at lumbar spine or femoral neck.

RESULTS:

The mean Z score for spine BMD was -0.19+/-0.7, and -0.03+/-0.85 for femoral neck BMD. There were no significant differences of Z score values compared to the general population. No significant correlation was found between BMD and disease duration, radiology sacroiliac score, and spine mobility. Densitometry showed osteopenia in 2 patients and osteoporosis in none.

CONCLUSION:

We found a slight reduction in BMD in premenopausal women with early AS, but the difference was not statistically significant. We discuss the factors related to its pathogenesis.

PMID:
10782832
[Indexed for MEDLINE]
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