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Bioorg Med Chem Lett. 2000 Apr 17;10(8):811-4.

Leukotriene B4 photoaffinity probes: design, synthesis and evaluation of new arylazide-1,3-disubstituted cyclohexanes.

Author information

1
Laboratoire de Chimie Biomoléculaire et des Interactions Biologiques, UPRESA-CNRS 5074, Faculté de Pharmacie, Montpellier, France.

Abstract

The synthesis and the binding affinities of new leukotriene B4 receptor photoaffinity probes, where a 1,3-disubstituted cyclohexane ring replaces the conjugated delta6,7 and delta8,9 double bonds of the natural eicosanoid, are described. One enantiomeric compound, 4b alpha, is specifically cross-linked upon photolysis to the recombinant leukotriene B4 receptor from human origin (h-BLTR) solubilized in a micellar medium. This probe appears as a good candidate for identifying the ligand binding site of this receptor.

PMID:
10782692
DOI:
10.1016/s0960-894x(00)00103-7
[Indexed for MEDLINE]

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