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Bioorg Med Chem Lett. 2000 Apr 17;10(8):715-7.

4-Thiazolidinones: novel inhibitors of the bacterial enzyme MurB.

Author information

1
Bristol-Myers Squibb Pharmaceutical Research Institute, Wallingford, CT 06492, USA.

Abstract

4-Thiazolidinones were synthesized and evaluated for their ability to inhibit the bacterial enzyme MurB. Selected 4-thiazolidinones displayed activity against the enzyme in vitro. This activity, coupled with the design principles of the thiazolidinones, supports the postulate that 4-thiazolidinones may be recognized as diphosphate mimics by a biological selector.

PMID:
10782671
DOI:
10.1016/s0960-894x(00)00073-1
[Indexed for MEDLINE]

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