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Bioorg Med Chem Lett. 2000 Apr 17;10(8):685-9.

Isoxazolines and isoxazoles as factor Xa inhibitors.

Author information

1
The DuPont Pharmaceuticals Company, Wilmington, Delaware 19880-0500, USA. james.r.pruitt@dupontpharma.com

Abstract

3,4,5-Trisubstituted isoxazolines (2) and isoxazoles (3) were prepared and evaluated for their in vitro and in vivo antithrombotic efficacy. They were compared to 3,5,5-trisubstituted isoxazolines (1) for Factor Xa selectivity and potency. They were also compared in an arterio-venous (A-V) shunt model of thrombosis.

PMID:
10782664
DOI:
10.1016/s0960-894x(00)00097-4
[Indexed for MEDLINE]

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