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Trends Biochem Sci. 2000 May;25(5):241-6.

Proteins binding to duplexed RNA: one motif, multiple functions.

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Dept of Biochemistry and Molecular Biology, New Jersey Medical School, UMDNJ, 185 South Orange Ave., Newark, NJ 07103-2714, USA.


Highly structured and double-stranded (ds) RNAs are adaptable and potent biochemical entities. They interact with dsRNA-binding proteins (RBPs), the great majority of which contain a sequence called the dsRNA-binding motif (dsRBM). This approximately 70-amino-acid sequence motif forms a tertiary structure that interacts with dsRNA, with partially duplexed RNA and, in some cases, with RNA-DNA hybrids, generally without obvious RNA sequence specificity. At least nine families of functionally diverse proteins contain one or more dsRBMs. The motif also participates in complex formation through protein-protein interactions.

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