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Trends Biochem Sci. 2000 May;25(5):215-21.

Regulation of mitochondrial metabolism by ER Ca2+ release: an intimate connection.

Author information

1
Dept of Biochemistry, School of Medical Sciences, University of Bristol, Bristol, UK BS8 1TD. g.a.rutter@bris.ac.uk

Abstract

New live-cell imaging techniques indicate that mitochondria exist in the living cell as a continuous interconnected mitochondrial reticulum, or 'MR', closely associated with the endoplasmic reticulum (ER). Ca2+ ions released from the ER in response to hormonal stimulation might thus be preferentially transferred into the mitochondrial matrix causing the local activation of ATP synthesis. Ca2+ uptake into the MR might also subtly modify the activity of ER Ca2+ release channels and thus the dynamics of cytosolic Ca2+ oscillations and waves.

PMID:
10782088
DOI:
10.1016/s0968-0004(00)01585-1
[Indexed for MEDLINE]

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