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Immunol Today. 2000 May;21(5):242-8.

Poxviral mimicry of complement and chemokine system components: what's the end game?

Author information

1
Dept of Microbiology and Immunology, University of Louisville School of Medicine, Louisville, KY 40292, USA. gjkotw01@gwise.louisville.edu

Abstract

Numerous viral proteins mimic host immunoregulatory proteins, both structurally and functionally. This phenomenon appears to underlie viral evasion of host defense. These viral immunomodulatory proteins block viral neutralization and destruction of infected cells, and are also able to influence their habitat, preserving habitats that favor their growth and that of their progeny. The end game seems to vary widely among viruses.

PMID:
10782056
[Indexed for MEDLINE]

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