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Immunol Today. 2000 May;21(5):228-34.

Natural cytotoxicity receptors that trigger human NK-cell-mediated cytolysis.

Author information

1
Dipartimento di Medicina Sperimentale, University of Genova, Italy. moretta@ermes.cba

Abstract

Natural killer (NK) cells can detect whether cells have undergone tumour transformation or viral infection. The discovery of specific inhibitory receptors for major histocompatibility complex class I molecules clarified the basis of this discrimination. However, the receptors responsible for NK-cell triggering in the process of natural cytotoxicity remained elusive until recently. Here, Alessandro Moretta and colleagues describe the identification and characterization of several such receptors.

PMID:
10782054
[Indexed for MEDLINE]

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