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Immunol Today. 2000 May;21(5):228-34.

Natural cytotoxicity receptors that trigger human NK-cell-mediated cytolysis.

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Dipartimento di Medicina Sperimentale, University of Genova, Italy.


Natural killer (NK) cells can detect whether cells have undergone tumour transformation or viral infection. The discovery of specific inhibitory receptors for major histocompatibility complex class I molecules clarified the basis of this discrimination. However, the receptors responsible for NK-cell triggering in the process of natural cytotoxicity remained elusive until recently. Here, Alessandro Moretta and colleagues describe the identification and characterization of several such receptors.

[Indexed for MEDLINE]

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