Send to

Choose Destination
See comment in PubMed Commons below
Immunol Today. 2000 May;21(5):228-34.

Natural cytotoxicity receptors that trigger human NK-cell-mediated cytolysis.

Author information

  • 1Dipartimento di Medicina Sperimentale, University of Genova, Italy.


Natural killer (NK) cells can detect whether cells have undergone tumour transformation or viral infection. The discovery of specific inhibitory receptors for major histocompatibility complex class I molecules clarified the basis of this discrimination. However, the receptors responsible for NK-cell triggering in the process of natural cytotoxicity remained elusive until recently. Here, Alessandro Moretta and colleagues describe the identification and characterization of several such receptors.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center