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Curr Opin Immunol. 2000 Jun;12(3):256-66.

Adapter proteins in lymphocyte antigen-receptor signaling.

Author information

1
Graduate Program of Immunology, University of Pennsylvania, The Leonard and Madlyn Abramson Family Cancer Research Institute, Philadelphia, PA 19104-6160, USA.

Abstract

Adapter molecules contain discrete modular domains that direct specific intermolecular interactions to orchestrate assembly of signaling complexes. A number of adapter proteins play critical roles in both positive and negative regulation of antigen-receptor signaling, influencing lymphocyte development and function.

PMID:
10781404
DOI:
10.1016/s0952-7915(00)00085-6
[Indexed for MEDLINE]

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