Pitfalls in the management of a child with mild haemophilia A and a traumatic hyphaema

C Hallet; C Willoughby; A Shafiq; S B Kaye; P H Bolton-Maggs

doi:10.1046/j.1365-2516.2000.00369.x

Pitfalls in the management of a child with mild haemophilia A and a traumatic hyphaema

Haemophilia. 2000 Mar;6(2):118-9. doi: 10.1046/j.1365-2516.2000.00369.x.

Authors

C Hallet¹, C Willoughby, A Shafiq, S B Kaye, P H Bolton-Maggs

Affiliation

¹ Department of Ophthalmology, Royal Liverpool Children's Hospital, Liverpool, UK.

PMID: 10781201
DOI: 10.1046/j.1365-2516.2000.00369.x

Abstract

A 12-year-old boy presented with a traumatic hyphaema that failed to settle with the standard treatment. Subsequent investigation showed that despite a normal APTT, he had a low factor VIII:C. Treatment with DDAVP precipitated further bleeding despite correction of the fVIII:C to normal, possibly caused by the vasodilation induced by the therapy. Bleeding was effectively treated with recombinant fVIII concentrate. DDAVP may be contraindicated in mild Haemophilia and von Willebrand patients for treatment of traumatic hyphaema.

Publication types

Case Reports

MeSH terms

Child
Contraindications
Deamino Arginine Vasopressin* / administration & dosage
Deamino Arginine Vasopressin* / adverse effects
Disease Management
Factor VIII / administration & dosage
Factor VIII / metabolism
Hemophilia A / complications*
Hemophilia A / drug therapy*
Hemostatics
Humans
Hyphema / drug therapy*
Hyphema / etiology
Male
Partial Thromboplastin Time
Recombinant Proteins / administration & dosage
Wounds and Injuries / complications*

Substances

Hemostatics
Recombinant Proteins
Factor VIII
Deamino Arginine Vasopressin