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Br J Cancer. 2000 Apr;82(8):1381-6.

Bisphosphonates in the adjuvant treatment of cancer: experimental evidence and first clinical results. International Bone and Cancer Study Group (IBCG).

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1
Department of Ob/Gyn, University of Heidelberg, Germany.

Abstract

Several animal models, as well as a number of cell culture experiments, indicate a prophylactic effect of bisphosphonates in respect of subsequent bone metastasis. Moreover, in preliminary clinical trials involving patients with advanced breast cancer and local or remote metastases, biophosphonates produced a reduction in new skeletal metastases. This overview summarizes and discusses the results of the latest investigations. It opens with a section on the pathophysiology of bone metastasis, which is followed by a report on animal models and first studies of bisphosphonate treatment as a new approach in systemic adjuvant therapy.

PMID:
10780514
PMCID:
PMC2363374
DOI:
10.1054/bjoc.1999.1077
[Indexed for MEDLINE]
Free PMC Article
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