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Nucleic Acids Symp Ser. 1999;(42):33-4.

Synthesis of oligonucleotides containing the oxidatively modified kappaB site: unique binding affinity to the NFkappaB p50 homodimer.

Author information

1
Faculty of Pharmaceutical Sciences, Teikyo University, Sagamiko, Kanagawa, Japan.

Abstract

Synthesis of oligonucleotide 26-mers including single 5-formyl-2'-deoxyuridine (1) or 5-formyl-2'-O-methyluridine (2) in place of thymidine at the kappaB site has been accomplished. One of the 26-mers with 1 was critically discriminated by the NFkappaB p50 homodimer in binding.

PMID:
10780365
[Indexed for MEDLINE]

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