Format

Send to

Choose Destination
See comment in PubMed Commons below
Can J Psychiatry. 2000 Apr;45(3):257-62.

On the pharmacotherapy of obsessive-compulsive disorder: is a consensus possible?

Author information

1
Louis-H Lafontaine Hospital, Montreal, Quebec. todorov@medclin.umontreal.ca

Abstract

OBJECTIVE:

To examine the efficacy and tolerability of clomipramine compared with the selective serotonin reuptake inhibitors (SSRIs) in the treatment of obsessive-compulsive disorder (OCD), bearing in mind the recent Expert Consensus Guidelines recommendation to use clomipramine after 2 to 3 failed SSRI trials.

METHOD:

The literature on the pharmacotherapy of OCD was critically examined.

RESULTS:

The available research evidence is not conclusive but suggests that clomipramine possesses greater anti-obsessional efficacy than do the SSRIs. In addition, when clomipramine is presented to patients in a positive way, and properly used in small initial doses with gradual increases, it seems to be tolerated as well as the SSRIs.

CONCLUSION:

Recently expressed opinions that clomipramine should be used to treat OCD after 2 to 3 failed SSRI trials are not supported by research evidence. Both clomipramine and the SSRIs may be used as first-line treatments for OCD.

PMID:
10779882
DOI:
10.1177/070674370004500304
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Atypon
    Loading ...
    Support Center