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FEMS Microbiol Lett. 2000 May 1;186(1):55-9.

Transposon targeting determined by resolvase.

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Department of Pharmaceutical Biosciences, Division of Microbiology, Uppsala University, Biomedicum, SE-751 23, Uppsala, Sweden.


The Mu-related transposon Tn5090, also called Tn402, was observed to be highly selective for targets clustered in or close to recombination sites of serine-type recombinases in plasmids R388 and RP1. Transposition to the par area of RP1 responded strongly to a deletion in the gene of resolvase ParA. A search in sequence databanks revealed further insertions of Tn5090/Tn402 close to different genes of resolvases. These results imply that the target selection of Tn5090 depends on a property that is shared among several serine recombinases.

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