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J Am Acad Dermatol. 2000 May;42(5 Pt 1):829-30.

Treatment with anti-tumor necrosis factor alpha (TNF-alpha) monoclonal antibody dramatically decreases the clinical activity of psoriasis lesions.

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Divisions of Clinical Pharmacology and Gastroenterology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, USA.


We treated a 57-year-old woman for refractory inflammatory bowel disease with a humanized anti-tumor necrosis factor alpha monoclonal antibody (Infliximab). The patient also had a 15-year history of Crohn's disease and a 20-year history of moderate to severe psoriasis. She received a single infusion of Infliximab (5 mg/kg). Two weeks after the infusion her psoriasis had dramatically improved in appearance. To our knowledge, our case is the first reported instance of successful anti-tumor necrosis factor alpha therapy in psoriasis.

[Indexed for MEDLINE]

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