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Cytogenet Cell Genet. 2000;88(1-2):159-62.

Characterization of a new TSPY gene family member in Yq (TSPYq1).

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  • 1Istituto di Clinica Neurologica, Universit√† di Milano, Ospedale Policlinico IRCCS, Chieti (Italy).

Abstract

We investigated subinterval 6E on the human Y chromosome, a region frequently deleted in infertile males. YAC yOX17, mapped within subinterval 6E by STS-PCR, was analyzed for the presence of new genes. TSPYq1, a member of the TSPY multi-copy gene family, was isolated and characterized from a yOX17 cosmid subclone. PCR and FISH analysis performed on normal subjects and on patients with microdeletions of Yq suggested the presence of multiple copies of TSPY in Yq.

PMID:
10773691
DOI:
15510
[PubMed - indexed for MEDLINE]
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