Send to

Choose Destination
Int J Antimicrob Agents. 2000 Apr;14(3):177-80.

Antimicrobial activity of psychotropic drugs: selective serotonin reuptake inhibitors.

Author information

Department of Microbiology, Hospital Universitario de Salamanca, Paseo de San Vicente 108, 37007, Salamanca, Spain.


Psychotropic drugs have been shown to have antimicrobial activity against several groups of microorganisms. Some of these drugs, such as the new antidepressant agents sertraline, fluoxetine and paroxetine are known to act as efflux pump inhibitors in human cells. Their activity has been studied, alone and combined with antibiotics, against bacterial species, mainly in multiply resistant strains. These agents have surprising activity, mainly against Gram positive microorganisms. They also show synergistic activity when combined with some antibiotics against several bacteria, shown by a decrease in MICs, that converts strains previously resistant to the category of sensitive, and modify physiological aspects related with pathogenicity.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center