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Arch Neurol. 2000 Apr;57(4):597-9.

Manganese intoxication.

Author information

1
Department of Neurology, College of Medicine, The Catholic University of Korea, Seoul.

Abstract

Manganese plays an important role as a cofactor in many enzymatic reactions in humans but in excess amounts can cause irreversible nervous system damage. Although manganism is a rare condition, it can be the cause of complex nervous system symptoms, especially in the setting of environmental exposure. Specifically, manganese is a well-known cause of dystonic parkinsonism. This article highlights several historical descriptions of the clinical manifestations, pathological changes, and attempted therapeutic intervention in manganese intoxication.

PMID:
10768639
DOI:
10.1001/archneur.57.4.597
[Indexed for MEDLINE]

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