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J Infect Dis. 2000 Apr;181(4):1421-7. Epub 2000 Apr 13.

Multiple drug-resistant Chlamydia trachomatis associated with clinical treatment failure.

Author information

1
Division of Infectious Diseases, Emory University School of Medicine, Atlanta, Georgia 30333, USA.

Abstract

In vitro susceptibility testing and genotyping were done on urogenital isolates of Chlamydia trachomatis from 3 patients, 2 of whom showed evidence of clinical treatment failure with azithromycin and one of whom was the wife of a patient. All 3 isolates demonstrated multidrug resistance to doxycycline, azithromycin, and ofloxacin at concentrations >4.0 microg/mL. Recurrent disease due to relapsing infection with the same resistant isolate was documented on the basis of identical genotypes of both organisms. This first report of clinically significant multidrug-resistant C. trachomatis causing relapsing or persistent infection may portend an emerging problem to clinicians and public health officials.

PMID:
10762573
DOI:
10.1086/315372
[Indexed for MEDLINE]

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