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Biol Cell. 2000 Jan;92(1):5-25.

Integrins: regulators of embryogenesis.

Author information

1
Université P.-et-M.-Curie, U.M.R.-CNRS 7622, Laboratoire de Biologie Moléculaire et Cellulaire du Développement, Equipe Adhesion et Migration Cellulaires, Paris, France.

Abstract

Integrins are heterodimeric transmembrane glycoproteins involved in cell-cell and cell-extracellular matrix adhesion. They also participate in cytoskeletal rearrangements, co-regulation of growth factor activities and activation of signal transductions. This review describes experimental approaches that have given new insights into the integrin functions during embryogenesis. Using anti-functional antibodies, peptide inhibitors of integrin-ligand interactions and genetic ablation of integrins results, this review will show that integrins are key molecules during early development of both invertebrates and vertebrates.

PMID:
10761694
DOI:
10.1016/s0248-4900(00)88760-2
[Indexed for MEDLINE]

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