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Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):4132-7.

Genetic mapping of a naturally occurring hereditary renal cancer syndrome in dogs.

Author information

1
Norwegian School of Veterinary Science, Department of Morphology, Genetics, and Aquatic Biology, Section of Genetics, Oslo. tora.jonasdottir@veths.no

Abstract

Canine hereditary multifocal renal cystadenocarcinoma and nodular dermatofibrosis (RCND) is a rare, naturally occurring inherited cancer syndrome observed in dogs. Genetic linkage analysis of an RCND-informative pedigree has identified a linkage group flanking RCND (CHP14-C05.377-C05.414-FH2383-C05. 771-[RCND-CPH18]-C02608-GLUT4-TP53-ZuBe Ca6-AHT141-FH2140-FH2594) thus localizing the disease to a small region of canine chromosome 5. The closest marker, C02608, is linked to RCND with a recombination fraction (theta) of 0.016, supported by a logarithm of odds score of 16.7. C02608 and the adjacent linked markers map to a region of the canine genome corresponding to portions of human chromosomes 1p and 17p. A combination of linkage analysis and direct sequencing eliminate several likely candidate genes, including tuberous sclerosis 1 and 2 genes (TSC1 and TSC2) and the tumor suppressor gene TP53. These data suggest that RCND may be caused by a previously unidentified tumor suppressor gene and highlight the potential for canine genetics in the study of human disease predisposition.

PMID:
10759551
PMCID:
PMC18172
DOI:
10.1073/pnas.070053397
[Indexed for MEDLINE]
Free PMC Article

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