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Am J Cardiol. 2000 Apr 1;85(7):913-5, A10.

Chronic treatment with phentermine combined with fenfluramine lowers plasma serotonin.

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  • Am J Cardiol 2000 Jun 15;85(12):1511.


As expected on the basis of published research in both humans and animals, treatment with phentermine/fenfluramine lowers plasma 5-hydroxytryptamine [corrected], whereas treatment with phentermine had no significant effect. In light of these findings, future research should focus on mechanisms other than increased plasma 5-hydroxytryptamine [corrected] to explain how fenfluramine increases the risk of primary pulmonary hypertension and valvular heart disease.

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