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Microbes Infect. 2000 Mar;2(3):295-304.

CD14, new aspects of ligand and signal diversity.

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Division of Infectious Diseases, Departments of Research and Internal Medicine, University Hospital, Hebelstrasse 20, 4031, Basel, Switzerland.


The glycosyl-phosphatidylinositol-linked glycoprotein CD14 is expressed in myeloid cells and serum. It binds Gram-negative and -positive bacterial cell wall components and endogenous phospholipids. Toll-like receptors, NF-kappaB and MAP kinases participate in CD14 signaling of inflammation. Alterations of CD14 in inflammatory diseases support a pathogenic role for this microbial receptor.

[Indexed for MEDLINE]

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