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Microbes Infect. 2000 Mar;2(3):289-94.

CR3: a general purpose adhesion-recognition receptor essential for innate immunity.

Author information

1
BioNebraska, Inc., 3820 NW 46thStreet, Lincoln, NE 68524, USA.

Abstract

CR3 (CD11b/CD18), a beta(2) integrin, has a key role in innate antimicrobial defenses, as evidenced by the leukocyte adhesion (CD18) deficiency syndrome in humans and the CD11b knockout mouse. CR3 is a highly versatile pattern-recognition receptor that activates leukocytes via signaling complexes and actin reorganization, mediates phagocytosis, and promotes leukocyte transmigration.

PMID:
10758405
DOI:
10.1016/s1286-4579(00)00299-9
[Indexed for MEDLINE]

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