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Microbes Infect. 2000 Mar;2(3):251-5.

Toll-like receptors.

Author information

1
Department of Immunology and Cell Biology, Mario Negri Institute, via Eritrea 62, 2015, Milan, Italy.

Abstract

Toll-like receptors (TLRs) are a growing family of molecules involved in innate immunity. Accumulating evidence suggests that TLR molecules are involved in signalling receptor complexes which recognise components of Gram-positive and Gram-negative bacteria and mycobacteria. Differential expression and regulation as well as distinct though overlapping ligand recognition patterns may underlie the existence of a vast TLR family. Apparent structural and functional redundancy may render certain outputs of the TLR family robust.

PMID:
10758401
DOI:
10.1016/s1286-4579(00)00303-8
[Indexed for MEDLINE]

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