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Int J Cancer. 2000 Mar 20;89(2):118-21.

High levels of TIMP-2 correlate with adverse prognosis in breast cancer.

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Laboratory of Tumor and Developmental Biology CHU, University of Liège, Sart-Tilman, Liège, Belgium.


TIMP-2 is an endogenous inhibitor of MMPs. Most data from model systems suggest that high levels of this inhibitor prevent metastasis. In human breast cancers, however, we show that high levels of TIMP-2 correlate with both shortened disease-free interval and overall survival. In primary breast cancers, TIMP-2 levels showed no significant relationship with either tumor size or axillary node status but correlated inversely with estrogen receptor levels. TIMP-2 levels also correlated significantly with those for TIMP-1. We conclude that high levels of endogenous TIMP-2, like other protease inhibitors such as PAI-1 and TIMP-1, correlate with progression of human breast cancer.

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