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Trends Biochem Sci. 2000 Apr;25(4):196-200.

Links between replication, recombination and genome instability in eukaryotes.

Author information

1
Ludwig Institute for Cancer Research, Cancer Center and Dept of Medicine, University of California-San Diego School of Medicine, La Jolla, CA 92093, USA.

Abstract

Double-strand breaks in DNA can be repaired by homologous recombination including break-induced replication. In this reaction, the end of a broken DNA invades an intact chromosome and primes DNA replication resulting in the synthesis of an intact chromosome. Break-induced replication has also been suggested to cause different types of genome rearrangements.

PMID:
10754554
PMCID:
PMC3635104
[Indexed for MEDLINE]
Free PMC Article

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