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Trends Biochem Sci. 2000 Apr;25(4):189-95.

Coping with replication 'train wrecks' in Escherichia coli using Pol V, Pol II and RecA proteins.

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Dept of Biological Sciences and Chemistry, University of Southern California, University Park, Los Angeles, CA 90089-1340, USA.


DNA replication machineries tend to stall when confronted with damaged DNA template sites, causing the biochemical equivalent of a major 'train wreck'. A newly discovered bacterial DNA polymerase, Escherichia coli Pol V, acting in conjunction with the RecA protein, can exchange places with the stalled replicative Pol III core and catalyse 'error-prone' translesion synthesis. In contrast to Pol V-catalysed 'brute-force, sloppier copying', another SOS-induced DNA polymerase, Pol II, plays a pivotal role in an 'error-free', replication-restart DNA repair pathway and probably involves RecA-mediated homologous recombination.

[Indexed for MEDLINE]

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