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Trends Biochem Sci. 2000 Apr;25(4):173-8.

Replication fork arrest and DNA recombination.

Author information

1
Laboratoire de Génétique Microbienne, Institut National de la Recherche Agronomique, 78352 Jouy en Josas Cedex, France. bmichel@biotec.jouy.inra.fr

Abstract

Replication arrests are associated with genome rearrangements, which result from either homologous or non-homologous recombination. Interestingly, proteins involved in homologous recombination are able to convert an arrested replication fork into a recombination intermediate, which promotes replication restart and thus presumably prevents genome rearrangements.

PMID:
10754549
DOI:
10.1016/s0968-0004(00)01560-7
[Indexed for MEDLINE]

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