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Cancer Lett. 2000 Apr 28;152(1):23-9.

The marine compound spisulosine, an inhibitor of cell proliferation, promotes the disassembly of actin stress fibers.

Author information

1
Centro de Biología Molecular 'Severo Ochoa' (CSIC-UAM), Universidad Autónoma de Madrid, 28049, Madrid, Spain.

Abstract

Spisulosine is a novel antiproliferative (antitumoral) compound of marine origin. In this work the molecular target for this toxic agent has been analyzed. In the presence of spisulosine, cultured cells change their morphology, first acquiring a fusiform morphology, and later becoming rounded without focal adhesions. Analysis of the cytoskeleton of treated cells indicate the absence of actin stress fibers.

PMID:
10754202
DOI:
10.1016/s0304-3835(99)00428-0
[Indexed for MEDLINE]

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